Two different versions of the original game were released. Puzzle Bobble was originally released in Japan only in June 1994 by Taito Corporation, running on Taito's B System hardware (with the preliminary title "Bubble Buster"). Then, 6 months later in December, the international Neo Geo version of Puzzle Bobble was released. It was almost identical aside from being in stereo and having some different sound effects and translated text.

When set to the US region the Neo-Geo version would display the alternative title "Bust a Move" and feature anti-drugs and anti-littering messages in the title sequence. The Bust-a-Move title was used for all subsequent games in the series in the United States and Canada, as well as for some (non-Taito published) console releases in Europe.